ABSTRACT
Transient hyperprolectinemia has been reported to follow unprovoked seizures. This study was conducted in 90 children aged 1-18 years of age. The study comprised of four groups: Group-1 consisted of children with epilepsy which was further subdivided into GTCS, CPS and SPS. Group-2 comprised of children having febrile convulsions. Group-3 comprised of children suffering from non-epileptic paroxysmal events like breath holding spell, syncope and pseudoseizures or conversion reaction. Group-4 consisted of children who served as controls. Blood sample was collected within two hours of the event in all the groups. The exact interval between the event and the collection of blood sample was noted. Serum prolactin level was estimated by ELISA technique. In the present study, significant elevation of serum prolactin level was observed only in the Group-1 (28.77+15.49ng/ml) as compared to controls (9.53+2.45ng/ml) and the highest levels were observed in children with GTCS. Maximum elevation of prolactin was seen within 15 to 30 minutes post ictally. As the prolactin levels become normal after two hours of post ictal period, the test looses its significance.
ABSTRACT
This case control study was carried out on 35 neonates born to pre-eclamptic/eclamptic mothers treated with magnesium sulphate and 35 neonates born to normal healthy mothers. Cases and controls were selected by inclusionexclusion criteria irrespective of body weight and maturity of the babies. Magnesium sulphate administered to mother in study group was according to Pritchard’s intramuscular regime (1984). The cord blood samples were collected just after birth in both study and control group and magnesium level was estimated by calorimetric method. Magnesium level was found to be significantly higher in study group (6.0305±0.08047) than controls (1.916± 0.300; p = 0.0001). There was a significant difference in Apgar scores of study and control group. A negative weak linear correlation was found between cord blood magnesium level and different neonatal parameter like apgar score, birth weight and gestestional age. A weak positive linear correlation was found between magnesium level and neonatal mortality which was also not significant.
ABSTRACT
The present study was carried out to study serum zinc levels for it’s prognostic significance as well as for it’s role in pathophysiology of febrile seizures, idiopathic epilepsy and acute CNS infections. In the present study, 100 cases who were admitted in our hospital during March 2009 to August 2010, aged between 1 month to 18 yrs were selected on the basis of clinical history, physical and CSF examination. They were grouped as groupA (pyogenic meningitis), group B (febrile seizures), group C (idiopathic epilepsy), group D (other acute CNS infections), group E (cerebral malaria) and group F (control). Cases of cerebral palsy, neuroanatomical malformations, neurobehavioural disorders, neurodegenerative disorders and drug induced neurological manifestations were not included in the present study. Mean serum zinc level was significantly lower in groups A, B & E, while no significant difference was observed in group C & D as compared to the control. No significant difference in serum zinc level was detected in relation to outcome and degree of consciousness in any of the study groups.